KTIVITAS ANTIFUNGI EKSTRAK ETANOL NEPHTHEA SP. TERHADAP MALASSEZIA FURFUR DAN TRICHOPHYTON RUBRUM

Hamida, Fathin and Yayah Siti Djuhariah, M.Si., Apt, YSD (2025) KTIVITAS ANTIFUNGI EKSTRAK ETANOL NEPHTHEA SP. TERHADAP MALASSEZIA FURFUR DAN TRICHOPHYTON RUBRUM. Jurnal Kesehatan Tambusai, 6 (2). pp. 8673-8681. ISSN 2774-5848

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Abstract

Mycosis infection is one of the infections that often occurs in Indonesia. These study aimed to analyze the antifungal activity of the ethanol extract of Nephthea sp. against Malassezia furfur and Trichophyton rubrum. Ethanol extract of Nephthea sp. was obtained by maceration using 96% ethanol solvent. The ethanol extract of Nephthea sp. was tested qualitatively for its secondary metabolite compound content, including alkaloids, tannins, flavonoids, saponins, and triterpenoids. The extract of Nephthea sp. was also tested for its ability to inhibit the growth of Malassezia furfur and Trichophyton rubrum fungi using the disc diffusion method. Antifungal activity is indicated by a clear zone (inhibition zone) formed around the disc paper. Ketoconazole (15 µg) was used as a positive control and 10% DMSO as a negative control. The screening data of secondary metabolite compounds and antifungal activity of ethanol extract of Nephthea sp. were described descriptively. Based on the screening test of secondary metabolite compounds, it was shown that the ethanol extract of Nephthea sp. positively contained alkaloids, saponins, and triterpenoids. Ethanol extract of Nephthea sp. had antifungal activity against Trichophyton rubrum at concentrations of 1000 mg/mL, 750 mg/mL, and 500 mg/mL. While antifungal activity against Malassezia furfur was not detected. Thus, it can be concluded that the ethanol extract of Nephthea sp. contains secondary metabolite compounds that have the potential as antifungals against Trichophyton rubrum with moderate inhibitory potency

Item Type:	Article
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User:	S.Si, M.Si FATHIN HAMIDA
Date Deposited:	10 Dec 2025 03:19
Last Modified:	10 Dec 2025 03:19
URI:	http://repository.istn.ac.id/id/eprint/14270

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