Aktivitas Antidiabetes Kombinasi Ekstrak Etanol Daun Sirih Merah (Piper crocatum) dan Buah Mahkota Dewa (Phaleria macrocarpa) Pada Tikus Diinduksi Streptozotosin-Nikotinamid

Teodhora, TDH and Agung Endro Nugroho, AEN and Gunawan Pamudji Widodo, GPW (2017) Aktivitas Antidiabetes Kombinasi Ekstrak Etanol Daun Sirih Merah (Piper crocatum) dan Buah Mahkota Dewa (Phaleria macrocarpa) Pada Tikus Diinduksi Streptozotosin-Nikotinamid. Sainstech Farma, Institut Sains Dan Teknologi Nasional.

Text peer reviewer_teodhora.pdf Download (1MB)

Abstract

Red betel (Piper crocatum) and Phaleria (Phaleria macrocarpa) are medicinal pants that can be used to overcome type II diabetes mellitus. This study aimed to determine the antidiabetic activity combination of ethanolic extract of red betel leaf and phaleria fruit in streptozotosin-nicotinamide-induced rats. The study was conducted using Wistar rats (Rattus norvegicus) divided into 5 groups. Group 1: normal control; Group 2: negative control (Na-CMC); Group 3: positive control (glibenclamide 5 mg/kg BW); groups 4 and 5 were combination group: ethanolic extract of dose groups 50:100 and 100:200 mg/kg BW. The diabetic rats was induced intraperitoneally with streptozotosin50 mg/kg BW and nicotinamide 110 mg/kg BW for group 1-5. Determination of fasting glucose levels used reagent Kit. The result showed that the percentage of hypoglycemic level of red betel leaf extract 50 mg/kg BW and phaleria macrocarpa fruit extract 100 mg/kg BW (combination I) were 24,32±2,07 within 14 days.

Item Type:	Other
Uncontrolled Keywords:	Kata Kunci : diabetes mellitus tipe-2, Phaleria macrocarpa, Piper crocatum
Subjects:	Z Bibliography. Library Science. Information Resources > ZA Information resources Z Bibliography. Library Science. Information Resources > ZA Information resources > ZA4450 Databases
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User:	TEODHORA ISTN
Date Deposited:	03 Sep 2020 10:02
Last Modified:	03 Sep 2020 10:02
URI:	http://repository.istn.ac.id/id/eprint/520

Actions (login required)

View Item