Developing transdermal patch from Momordica charantia L. fruit using polyvinyl alcohol and ethyl cellulose potentially as anti-inflammatory dosage form

TETI INDRAWATI, TETI and Zainur Rahman Hakim Rahman Hakim, Zainur Rahman Hakim and Fiqi Fatimah, Fiqi Developing transdermal patch from Momordica charantia L. fruit using polyvinyl alcohol and ethyl cellulose potentially as anti-inflammatory dosage form. [Teaching Resource]

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Abstract

Abstract Introduction: Anti-inflammatory medication is currently sufficiently developed for the ease of application and effectiveness of therapy. Development of natural ingredients that are applied through the skin is needed to get a profitable product. This study aimed to develop bitter melon (Momordica charantia L.) fruit as an anti-inflammatory agent using transdermal patch preparations. Materials and Methods: Dried bitter melon powder was macerated using 96% ethanol, followed by evaporation until a viscous extract was obtained. Bitter melon fruit extract (BMFE) 30% was prepared into three patch transdermal preparations using combinations of polyvinyl alcohol (PVA) and ethyl cellulose (EC) as bases. A mixture of BMFE, propylene glycol, and glycerin was added to the bases and mixed until homogeneous. The entire mass was poured into a mold, coated with aluminum foil, allowed to stand for 24 h, and dried in an oven at 40 °C for 30 min. All preparations of the transdermal patch were evaluated for their physical and chemical characteristics as well as their anti�inflammatory effects Results: All transdermal patch preparations had solid form, visible brown, weight 0.424 -0.432 g, thickness 0.344 – 0.320 mm, folding endurance of more than 300, pH 4.84 – 4.87, and hygroscopicity 6.50 - 6.99 %. All preparations showed a decrease in the diameter of the edema, but this was not significant; after the 90th minute, the edema diameter was significantly reduced. Conclusion: This study showed that BMFE can be used for anti-inflammatory patch preparation and has the potential to be developed as a transdermal anti-inflammatory dosage form. Keywords: Anti-inflammation; Bitter melon; Characterization; Transdermal patch

Item Type: Teaching Resource
Subjects: L Education > L Education (General)
Depositing User: Prof.Dr.MS Teti Indrawati
Date Deposited: 06 Mar 2023 04:58
Last Modified: 06 Mar 2023 04:58
URI: http://repository.istn.ac.id/id/eprint/6017

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